Here's what I run for the majority of PvE situations where I don't need buildings. I have very minimal issues with 2 orb situations.
I load up my first 2 orbs with spells like Hurricane and Ensnaring Roots for disruption/keeping my units safe from melee threats. The Matter Mastery I usually keep for rPvE in case I get Twilight enemies so I can keep Willzappers under control. I'll switch it out for Curse of Oink, or Coldsnap is another good option.
I personally usually avoid Coldsnap because Frozen enemies take 50% less damage, and Curse of Oink because dealing damage can cancel the